Tobacco use is a major avoidable cause of mortality and morbidity, accounting for more than 480,000 deaths each year in the United States and Canada. Smoking is the cause of many diseases including cardiovascular diseases, chronic obstructive pulmonary disease, stroke, and lung cancer. Tobacco dependence mimics a chronic disease with only a minority of tobacco users abstinent permanently after a first quit attempt, while, most of them fail or relapse since first quit attempt. Tobacco use causes a huge economic burden to individual smokers and the whole society, accounting for 96 billion dollars’ expenditure in direct medical cost each year and 97 billion dollars in lost productivity.
Tobacco dependence |
It was reported that more than 70% of the 45 million smokers were willing to quit in the United States and almost half of these smokers had an attempt to quit. Unfortunately most of those attempting failed, only 4-7% of the 19 million adults who tried to quit in year 2005 achieved successful cessation.
The Tobacco Use and Dependence Clinical Practice Guidelines of 2008 updated Public Health Service Clinical Practice and recommended the use of pharmacotherapy for all smokers who want to make attempts to quit, except those having contradictions or some specific population for whom insufficient evidence of effectiveness exists (i.e., pregnant women, smokeless tobacco users, light smokers, and adolescents). It has suggested smoking cessation intervention should include at least one Food and Drug Administration (FDA) approved first-line smoking cessation Viagra medication online here.
Currently, there are seven first-line medications approved by the U.S. FDA which can help increase long-term smoking abstinence rates reliably. They are varenicline, bupropion SR, and nicotine replacement therapy (NRT) including: nicotine gum, nicotine inhaler, nicotine lozenge, nicotine nasal spray, and nicotine patch.
There are a few review and clinical trial studies, which provide such evidence that increased smoking cessation medication use led to higher abstinence rates. For instance, a review of 132 trials indicated that the risk ratio (RR) of abstinence for any form of NRT compared to control was 1.58 (95% confidence interval [CI]: 1.50-1.66). A systematic review and meta- analysis of effectiveness of smoking cessation therapies identified 12 randomized control trials, which used bupropion versus placebo and yielded odds ratios (OR) ranging from 1.72 to 2.64 compared with placebo at 3 months and yielded ORs ranging from 1.10 to 2.21 compared with placebo at 1 year. Bupropion can also delay relapse after successful abstinence for the smokers.
Racial/ethnic disparities in smoking cessation have been consistently documented in epidemiologic studies. The 2008 Clinical Practice Guideline recommended evaluating and enhancing smoking cessation interventions among racial and ethnic minority populations. A study conducted by Cokkinides et al which examined racial and ethnic disparities in smoking cessation interventions using 2005 National Health Interview Survey data has shown that black and Hispanic smokers are less likely to seek advice for quitting or use any smoking cessation intervention in the quit attempt compared to white smokers and this result is consistent even after controlling for socioeconomic and health care related factors. A review of published studies examining smoking cessation treatment interventions among ethnic and minority populations in the US has concluded that racial and ethnic minority populations are interested in smoking cessation and willing to quit. However, variations existed in the quitting outcomes across different studies among minority population due to variations in intervention and study design, also, the evaluations of outcomes by using pharmacotherapy are quite limited. Moreover, evaluation of racial disparity in using pharmacotherapy is limited.
Although there were limited evaluations of pharmacotherapy, the existing data supported use of pharmacotherapy in addition to counseling for enhancing abstinence outcomes. Further attention to the level of individual smoking, variability in smoking patterns, and use of other tobacco products is needed. Our study aims to assess whether there is also racial/ethnic disparities in smoking cessation medication use, which may affect smoking cessation treatment outcome. The primary hypothesis is race is a significant factor of using smoking cessation pharmacotherapy. There is variation in pharmacotherapy use between different ethnic groups. Secondary hypothesis is except race, there are also some other factors that might affect the use of pharmacotherapy for smoking cessation, for instance, health insurance. Understanding the racial disparity in smoking cessation medication use among different racial groups can help us identify certain specific minority groups who may have a barrier to receive smoking cessation medication and develop culturally appropriate interventions to these minority groups.
Thus, understanding racial and ethnic differences in the provision or utilization of smoking cessation medication is integral in reducing tobacco use among minority groups.